Title: Allele-specific Disparity in Breast Cancer
نویسندگان
چکیده
This paper presented the authors' search for allele-specific disparity in breast cancer using paired blood tumor samples from a large cohort of breast cancer patients in different stages. Using a workflow/algorithm developed in this paper using B-allele frequency and log R ratio of Illumina SNP data to estimate Euclidean distances, the authors were able to detect SNPs with substantial difference between blood and tumor with high occurence frequencies among the patients. The results are consistent with known genes for breast cancer and the frequency increases with stages of breast cancer development.
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